What should you do if someone has used synthetic marijuana? For this reason, the terms synthetic cannabis, or synthetic marijuana, are incorrect. Synthetic cannabis is a relatively new drug. There8217;s limited information available about its short- and long-term effects. But it8217;s been reported to have some side effects similar to cannabis, along with with some additional negative and more harmful side effects, including: Synthetic cannabinoids produce a similar effect to smoking cannabis. Reported effects include: Case reports suggest that chronic use leads to the development of tolerance, subsequently increasing drug use and concomitant heightened risk of experiencing negative mental and medical health effects. Users of SM products appear to have a variety of physical effects ranging from nausea to more serious sympathomimetic-like symptoms, such as psychomotor agitations, abnormal vital signs, including hypertension and tachycardia, diaphoresis, and palpitations, as mentioned previously . Also, even though infrequently associated with side effects from smoking SM, clinical case reports have described generalized to see him convulsions secondary to the usage of 4 different synthetic cannabis derivatives, JWH-018, JWH-081, JWH-250, and AM-2201 .